The molecule, in three dimensions
- Heavy atoms
- 236
- Bonds
- 238
- Composition
- C149 N44 O42 S1
- Rings
- 3
- Metal centre
- None
- Chain length
- 29 residues
Every heavy atom is placed from the sequence with ideal bond lengths and angles, so the connectivity is exact. The pose is idealised, an ideal helix, and is not a measured conformation. Identity for the lot in stock is confirmed by LC-MS on its certificate.
Molecular data
| Molecular formula | C149H246N44O42S |
|---|---|
| Molecular weight | 3357.93 Da |
| Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg |
| Sequence length | 29 residues |
| CAS / identifier | 86168-78-7 |
| Physical form | Lyophilized powder |
| Available sizes | 10mg |
How it works
-
GHRH-R
GHRH Receptor Agonism
Sermorelin binds growth hormone-releasing hormone receptors on anterior-pituitary somatotrophs, stimulating the synthesis and pulsatile release of endogenous growth hormone rather than supplying it exogenously.
- Activates pituitary somatotrophs
- Pulsatile GH release
- Endogenous secretion
-
GH → IGF-1
Downstream IGF-1 Signaling
Raised growth hormone is followed by hepatic production of insulin-like growth factor 1 (IGF-1), the principal mediator of GH signalling in muscle, bone, connective tissue and lipid metabolism.
- Hepatic IGF-1 synthesis
- Protein anabolism
- Lipolytic signaling
-
Feedback
Preserved Physiologic Rhythm
Because the action is upstream at the pituitary, GH output remains subject to somatostatin and IGF-1 negative feedback, preserving the endogenous secretory rhythm rather than a fixed exogenous level.
- Somatostatin-regulated
- Negative feedback intact
- Natural pulsatility
-
Upstream
Upstream, Not Exogenous
Unlike recombinant HGH, which supplies growth hormone directly, Sermorelin acts on the pituitary to release endogenous GH - preserving the hypothalamic-pituitary axis and its regulatory checkpoints.
- Works upstream of GH
- HP axis preserved
- Self-limiting response
-
Half-Life
Short Plasma Half-Life
Sermorelin has a brief plasma half-life on the order of minutes, producing transient GH pulses that more closely resemble natural secretory bursts than the sustained elevation seen with exogenous GH.
- ~10-20 min half-life
- Transient GH pulses
- Mimics physiology
-
Sequence
GHRH(1-29) Active Fragment
Sermorelin corresponds to the first 29 amino acids of human GHRH - the shortest fully active N-terminal sequence - making it a well-characterized research probe of the somatotropic axis.
- 29-residue peptide
- Fully active fragment
- Well-characterized
What the research shows
-
Endocrine
Growth Hormone Axis
Used as a research probe of pituitary GH secretory reserve; the GHRH stimulation test has historically been employed to assess somatotroph function.
-
Body Composition
Body Composition Models
GH secretagogues are studied for their influence on lean body mass, fat mass, and metabolic rate in models of age- or disease-related GH decline.
-
Sleep Architecture
Slow-Wave Sleep
Endogenous GH release is tightly coupled to slow-wave sleep, so GHRH analogs are studied to explore the link between the somatotropic axis and sleep architecture.
-
Aging Research
Somatopause
Age-related decline in GH and IGF-1 - termed somatopause - is modelled with GHRH analogs to study changes in secretory patterns.
Specification
| Compound Class | Growth hormone-releasing hormone (GHRH) analog |
|---|---|
| Research Name | Sermorelin (GHRH 1-29) |
| Sequence | N-terminal 29-amino-acid fragment of human GHRH |
| Target | GHRH receptor (pituitary somatotrophs) |
| Form | Lyophilized powder |
| Molecular Weight | 3,357.93 g/mol |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Half-Life | ~10-20 minutes (plasma) |
| Storage | -20°C for long-term stability |
| Solubility | Water-soluble |
| COA | Included with every order |
| Molecular Formula | Available on request |
| Appearance | White to off-white powder |
| Quantity | 5mg |
| Stability | 24 months from manufacture date when stored properly |
How it's tested
Every lot of Sermorelin released to the catalog carries a third-party certificate of analysis. 5 documented lots are on file for this compound, with reported HPLC purity from 99.03% to 99.84% (mean 99.40%), issued by Accurate Test Labs and Freedom Diagnostics. 4 of 5 certificates record identity as confirmed.
- Documented lots
- 5
- Reported purity
- 99.03% to 99.84%
- Mean purity
- 99.40%
- Issuing labs
- Accurate Test Labs, Freedom Diagnostics
- 2026-09-15 Lot SM-091126-10Accurate Test Labs 99.03% View certificate
- 2026-08-17 Lot Auth2608070240Freedom Diagnostics 99.84% View certificate
- 2026-07-22 Lot Auth2607220666Freedom Diagnostics 99.63% View certificate
Frequently asked questions
What is Sermorelin?
Sermorelin is a synthetic analog of the first 29 amino acids of growth hormone-releasing hormone (GHRH) - the shortest fully active fragment. It is studied for pituitary stimulation of endogenous growth hormone secretion in a pulsatile pattern.
How is Sermorelin different from HGH?
Recombinant HGH supplies growth hormone directly, whereas Sermorelin stimulates endogenous GH release by acting upstream at the pituitary. This preserves the hypothalamic-pituitary feedback loop and a more physiologic secretory rhythm.
What is the molecular weight and purity?
Sermorelin has a molecular weight of 3,357.93 g/mol. Every vial is supplied at ≥99% purity, verified by HPLC, with a Certificate of Analysis included.
How should it be stored?
Keep lyophilized vials at -20°C for long-term stability, protected from light and moisture.
Is this product for human use?
No. Sermorelin is sold strictly as a research compound for laboratory and in-vitro use only. It is not intended for human or animal consumption, diagnosis, or treatment.
Related monographs
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.