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The Eon standard
High Purity Guarantee
Your results are only as good as your compound. Every lot of GHK-Cu is tested by an independent ISO/IEC 17025-accredited lab in the USA. 99%+ purity isn't a target here. It's the requirement. Don't take our word for it: test any vial at an accredited lab of your choice. If HPLC purity comes back under 99%, we refund your order and pay for the test.
Size
50mg
Purity
99%+ by HPLC · guaranteed
Identity
Confirmed by mass spec
Lab
Accurate Test Labs · ISO/IEC 17025
About this compound
GHK-Cu is a copper peptide made of three amino acids. It occurs naturally and was first isolated from human plasma in 1973. It is among the more extensively characterised peptides in dermal research. Studies have measured how much collagen skin cells produce after exposure, and how the surrounding tissue structure changes. Levels in plasma fall with age, and that finding is what drove most of the research that followed.
The numbers that define GHK-Cu and how it is being studied. For laboratory research use only.
4000+
Genes Modulated
Up- or down-regulated in human cell lines
3
Amino Acids
Gly-His-Lys tripeptide carrying a copper(II) ion
4
Research Areas
Dermal Models
Hair Follicle Models
Gene Expression
60%
Plasma GHK Decline
About 200 ng/mL at age 20, 80 ng/mL by age 60
How It Works
How GHK-Cu works
The pathways GHK-Cu acts on - and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
Copper Transport & Signaling
Copper Delivery
GHK-Cu chelates copper(II) ions and delivers them to cells. Copper-dependent enzymes involved in collagen crosslinking, antioxidant activity and tissue remodelling have been measured following exposure.
High-affinity copper(II) binding
Lysyl oxidase activity measured in collagen crosslinking
Superoxide dismutase activity measured
ECM Remodelling
Collagen Synthesis
Fibroblast production of type I and III collagen, glycosaminoglycans and decorin has been measured in culture, alongside changes in extracellular matrix architecture.
70% higher collagen synthesis vs controls in fibroblast culture
Glycosaminoglycan production measured
Decorin synthesis for matrix organization
Genomic Reprogramming
Gene Modulation
Gene expression work reports changes across 4,000+ human genes following GHK-Cu exposure - among the broadest transcriptional footprints recorded for a short peptide.
4,000+ genes modulated toward health
Raised DNA repair gene expression reported
Suppresses inflammatory gene expression
Uses & Applications
What GHK-Cu is researched for
The main areas GHK-Cu is being studied for - and the study-reported figures behind them.
Dermatology
Dermal Models
Collagen, elastin and glycosaminoglycan synthesis measured in fibroblast culture. Studied extensively in wound-closure and dermal-ageing models.
Trichology
Hair Follicle Models
Associated with larger follicle size, follicle growth and hair-cycle transition in preclinical models.
Genomics
Gene Expression
Expression changes reported across 4,000+ genes, including DNA repair, antioxidant and inflammatory pathways.
Antioxidant
Antioxidant Enzyme Activity
Chelates free copper, with lower oxidative-damage markers and raised superoxide dismutase activity measured in the same systems.
Study-reported magnitudes
Representative figures from published research. Bars fill as you scroll.
Collagen Synthesis70%
Wound Contraction Rate65%
Antioxidant Capacity80%
Anti-Inflammatory Effect75%
Figures are representative of published research findings and shown for reference.
Molecular Structure
The GHK-Cu molecule
An interactive 3D model rendered from the compound record - rotate and explore its structure.
Copper-coordination complex
Molecular formula
C₁₄H₂₄CuN₆O₄
Molecular weight
403.9 g/mol
Sequence length
3 residues
CAS / ID
49557-75-7
Physical form
Lyophilized powder
Documented purity
≥99% by HPLC
Compound Information
Full specification
Sequence
Gly-His-Lys-Cu(II)
Molecular Weight
403.9 Da
Molecular Formula
C₁₄H₂₄CuN₆O₄
Form
Lyophilized powder
Purity
≥99% (HPLC verified)
Testing
Third-party HPLC, Mass Spec, Endotoxin
Storage
-20°C for up to 24 months
Solubility
Water-soluble
COA
Included with every order
FAQ
Common questions about GHK-Cu
GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper-binding tripeptide first isolated from human plasma in 1973 by Dr. Loren Pickart. It is found in human blood, saliva, and urine, with plasma levels declining from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60.
Preclinical research has studied GHK-Cu in wound-closure and dermal models, including collagen and glycosaminoglycan synthesis; recruitment of immune and endothelial cells to injury sites; anti-inflammatory and antioxidant activity; and expression changes across over 4,000 genes.
GHK-Cu is not FDA approved as a drug. It is available as a research peptide and is also found in some cosmetic formulations. The lyophilized material sold here is for in vitro research purposes only.
GHK-Cu has been studied in cultured cell systems and in animal models, with copper binding, collagen-related gene expression and tissue-remodelling endpoints. Concentrations and endpoints differ between experiments.
GHK-Cu consists of three amino acids - glycine, histidine, and lysine - complexed with a copper(II) ion. The molecular formula is C₁₄H₂₄CuN₆O₄ with a molecular weight of approximately 403.9 Da. The histidine residue provides the primary copper-binding site.
Lyophilized GHK-Cu should be stored at -20°C for maximum stability (up to 24 months). Avoid repeated freeze-thaw cycles and protect from light.
Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
