The molecule, in three dimensions
- Heavy atoms
- 94
- Bonds
- 98
- Composition
- C63 N17 O14
- Rings
- 4
- Metal centre
- None
- Chain length
- 10 residues
Every heavy atom is placed from the sequence with ideal bond lengths and angles, so the connectivity is exact. The pose is idealised, an extended chain, and is not a measured conformation. Identity for the lot in stock is confirmed by LC-MS on its certificate.
Molecular data
| Molecular formula | C63H83N17O14 |
|---|---|
| Molecular weight | 1302.5 Da |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Sequence length | 10 residues |
| CAS / identifier | 374675-21-5 |
| Physical form | White lyophilized powder |
| Available sizes | 10mg |
How it works
-
GPR54 Agonist
KISS1R / GPR54 Activation
Kisspeptin-10 is the shortest active fragment of the KISS1 gene product and binds KISS1R (GPR54) on hypothalamic GnRH neurons - the most potent known endogenous trigger of GnRH neuron activity.
-
GnRH ↑
GnRH Pulse Generation
Receptor activation evokes pulsatile GnRH secretion into the hypophyseal portal circulation, with both the frequency and amplitude of GnRH pulses measured rather than output alone.
-
LH / FSH ↑
Gonadotropin Release
Downstream of GnRH, the pituitary releases luteinizing hormone (robust) and follicle-stimulating hormone (more modest), letting researchers probe upstream control of the gonadal axis.
What the research shows
-
Reproductive Neuroendocrinology
GnRH Axis Probing
Used to evoke discrete LH pulses, enabling characterization of GnRH pulsatility and pituitary responsiveness in controlled models.
-
Fertility Research
Gonadotropin Response
Studied as a stimulus of endogenous LH/FSH to distinguish hypothalamic from pituitary components of reproductive dysfunction.
-
Development
Pubertal Signaling
Investigated for the role of KISS1/GPR54 signaling in the onset and timing of puberty.
Specification
| Also Known As | KP-10, Metastin 45-54, Kisspeptin-112-121 |
|---|---|
| Type | Decapeptide - KISS1R/GPR54 agonist |
| CAS Number | 374675-21-5 |
| Molecular Formula | C63H83N17O14 |
| Molecular Weight | 1,302.5 g/mol |
| Amino Acid Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Physical Appearance | White lyophilized powder |
| Purity | ≥99% (HPLC) |
| Content | 10 mg per vial |
How it's tested
Every lot of Kisspeptin released to the catalog carries a third-party certificate of analysis. 3 documented lots are on file for this compound, with reported HPLC purity from 99.08% to 99.75% (mean 99.52%), issued by Accurate Test Labs and Freedom Diagnostics. 2 of 3 certificates record identity as confirmed.
- Documented lots
- 3
- Reported purity
- 99.08% to 99.75%
- Mean purity
- 99.52%
- Issuing labs
- Accurate Test Labs, Freedom Diagnostics
- 2026-09-03 Lot KPT-090226-10Accurate Test Labs 99.75% View certificate
- 2026-06-24 Lot Auth2606240350Freedom Diagnostics 99.08% View certificate
- 2026-01-09 Lot KISS12172025-JFreedom Diagnostics 99.72% View certificate
Frequently asked questions
What is Kisspeptin-10?
Kisspeptin-10 (KP-10) is a synthetic decapeptide corresponding to the C-terminal active fragment of the kisspeptin family encoded by the KISS1 gene. It is a high-affinity agonist of the KISS1R (GPR54) receptor.
How does it differ from Kisspeptin-54?
Kisspeptin-54 is the longer parent peptide; Kisspeptin-10 retains the C-terminal decapeptide that carries full receptor activity, with a shorter sequence and faster in-vivo clearance.
What is GPR54 / KISS1R?
It is the G-protein-coupled receptor for kisspeptins, expressed on GnRH neurons; its activation is essential for normal reproductive-axis function.
How is it stored?
Supplied as a lyophilized powder; store at -20°C, protected from light and moisture. Research use only.
Related monographs
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.