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The Eon standard
High Purity Guarantee
Your results are only as good as your compound. Every lot of Kisspeptin is tested by an independent ISO/IEC 17025-accredited lab in the USA. 99%+ purity isn't a target here. It's the requirement. Don't take our word for it: test any vial at an accredited lab of your choice. If HPLC purity comes back under 99%, we refund your order and pay for the test.
Size
10mg
Purity
99%+ by HPLC · guaranteed
Identity
Confirmed by mass spec
Lab
Accurate Test Labs · ISO/IEC 17025
About this compound
Kisspeptin-10 is a ten amino acid peptide. It is the active piece of a longer peptide called kisspeptin-54. It binds a receptor named KISS1R. Studies have measured what happens in the hypothalamus after it binds, and how that signal moves down the reproductive hormone axis. Its discovery changed how the field understood where that signal begins.
The numbers that define Kisspeptin and how it is being studied. For laboratory research use only.
10
Amino Acids
Decapeptide (KP-10)
GPR54
Target Receptor
KISS1R high-affinity agonist
0.85 nM
KISS1R Potency (EC50)
Calcium mobilization in a receptor cell line
~4 min
Plasma Half-Life
Measured in human plasma
How It Works
How Kisspeptin works
The pathways Kisspeptin acts on - and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
KISS1R / GPR54 Activation
GPR54 Agonist
Kisspeptin-10 is the shortest active fragment of the KISS1 gene product and binds KISS1R (GPR54) on hypothalamic GnRH neurons - the most potent known endogenous trigger of GnRH neuron activity.
GnRH Pulse Generation
GnRH ↑
Receptor activation evokes pulsatile GnRH secretion into the hypophyseal portal circulation, with both the frequency and amplitude of GnRH pulses measured rather than output alone.
Gonadotropin Release
LH / FSH ↑
Downstream of GnRH, the pituitary releases luteinizing hormone (robust) and follicle-stimulating hormone (more modest), letting researchers probe upstream control of the gonadal axis.
Uses & Applications
What Kisspeptin is researched for
The main areas Kisspeptin is being studied for - and the study-reported figures behind them.
Reproductive Neuroendocrinology
GnRH Axis Probing
Used to evoke discrete LH pulses, enabling characterization of GnRH pulsatility and pituitary responsiveness in controlled models.
Fertility Research
Gonadotropin Response
Studied as a stimulus of endogenous LH/FSH to distinguish hypothalamic from pituitary components of reproductive dysfunction.
Development
Pubertal Signaling
Investigated for the role of KISS1/GPR54 signaling in the onset and timing of puberty.
Study-reported magnitudes
Representative figures from published research. Bars fill as you scroll.
LH Pulse Response (animal & human models)robust
KISS1R Receptor Affinityhigh
FSH Responsemoderate
Figures are representative of published research findings and shown for reference.
Molecular Structure
The Kisspeptin molecule
An interactive 3D model rendered from the compound record - rotate and explore its structure.
C63H83N17O14
Molecular formula
C63H83N17O14
Molecular weight
1302.5 g/mol
Sequence length
10 residues
CAS / ID
374675-21-5
Physical form
White lyophilized powder
Documented purity
≥99% by HPLC
Compound Information
Full specification
Also Known As
KP-10, Metastin 45-54, Kisspeptin-112-121
Type
Decapeptide - KISS1R/GPR54 agonist
CAS Number
374675-21-5
Molecular Formula
C63H83N17O14
Molecular Weight
1,302.5 g/mol
Amino Acid Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Physical Appearance
White lyophilized powder
Purity
≥99% (HPLC)
Content
10 mg per vial
FAQ
Common questions about Kisspeptin
Kisspeptin-10 (KP-10) is a synthetic decapeptide corresponding to the C-terminal active fragment of the kisspeptin family encoded by the KISS1 gene. It is a high-affinity agonist of the KISS1R (GPR54) receptor.
Kisspeptin-54 is the longer parent peptide; Kisspeptin-10 retains the C-terminal decapeptide that carries full receptor activity, with a shorter sequence and faster in-vivo clearance.
It is the G-protein-coupled receptor for kisspeptins, expressed on GnRH neurons; its activation is essential for normal reproductive-axis function.
Supplied as a lyophilized powder; store at -20°C, protected from light and moisture. Research use only.
Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
