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The Eon standard
High Purity Guarantee
Your results are only as good as your compound. Every lot of Semax is tested by an independent ISO/IEC 17025-accredited lab in the USA. 99%+ purity isn't a target here. It's the requirement. Don't take our word for it: test any vial at an accredited lab of your choice. If HPLC purity comes back under 99%, we refund your order and pay for the test.
Size
10mg
Purity
99%+ by HPLC · guaranteed
Identity
Confirmed by mass spec
Lab
Accurate Test Labs · ISO/IEC 17025
About this compound
Semax is a seven amino acid peptide developed at a Russian research institute. Part of its sequence comes from ACTH, a hormone, and the rest is a short tail that keeps enzymes from breaking it down. Research in rodent models has measured BDNF, a protein involved in neuron growth, along with dopamine and serotonin activity. Despite the ACTH origin, it shows no stress hormone activity in testing.
The numbers that define Semax and how it is being studied. For laboratory research use only.
7
Amino Acids
ACTH(4-10) synthetic analog
2.4 nM
Membrane Binding (Kd)
Specific, reversible binding to brain membranes
>1 hr
Half-Life With Membranes
Measured by tritium label and HPLC
4
Research Areas
Memory & Learning Models
Cerebral Ischemia
BDNF Signalling
How It Works
How Semax works
The pathways Semax acts on - and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
BDNF Modulation
Neurotrophic
Brain-derived neurotrophic factor (BDNF) levels up to 1.4-fold baseline have been measured in specific brain regions, alongside neuronal survival and synaptic plasticity endpoints.
BDNF expression up to 1.4× measured
Neuronal survival and growth measured
Synaptic plasticity measured
Serotonin & Dopamine Modulation
Neurotransmitter
Research demonstrates Semax modulates serotonergic and dopaminergic systems, influencing mood regulation, attention, and cognitive processing in preclinical models.
Modulates serotonin metabolism
Influences dopaminergic signaling
Affects noradrenergic pathways
Ischemic Models
Neuroprotective
In ischemic stroke models, infarct volume, inflammatory gene expression and neuronal survival under oxygen deprivation are the recorded endpoints.
Infarct volume measured in stroke models
Anti-inflammatory gene modulation
Neuronal oxidative stress markers measured
Uses & Applications
What Semax is researched for
The main areas Semax is being studied for - and the study-reported figures behind them.
Cognitive
Memory & Learning
Cognitive function, memory consolidation and attention measures are recorded in animal models. The Russian pharmaceutical formulation has been approved there as a nootropic since 2011.
Neuroprotection
Cerebral Ischemia Models
Infarct volume and neuronal survival are measured in cerebral ischemia models. The Russian pharmaceutical formulation is used clinically there; that use does not extend to this research material.
Neurotrophic
BDNF & Neurotrophin Signalling
Neurotrophin and receptor expression are measured, alongside neuronal plasticity endpoints.
Anti-Inflammatory
Immune Modulation
Lower pro-inflammatory cytokines and altered oxidative stress-related gene expression are measured in hippocampal tissue.
Study-reported magnitudes
Representative figures from published research. Bars fill as you scroll.
BDNF Expression (fold change)140%
Cognitive Performance (animal)65%
Neuroprotection (ischemia)78%
Anti-Inflammatory Effect60%
Figures are representative of published research findings and shown for reference.
Molecular Structure
The Semax molecule
An interactive 3D model rendered from the compound record - rotate and explore its structure.
C37H51N9O10S
Molecular formula
C37H51N9O10S
Molecular weight
813.93 g/mol
Sequence length
7 residues
Physical form
Lyophilized Powder
Documented purity
≥99% by HPLC
Compound Information
Full specification
Strength
10mg
Molecular Formula
C37H51N9O10S
Molecular Weight
813.93 g/mol
Purity
>99% (HPLC)
Form
Lyophilized Powder
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Origin
Synthetic analog of ACTH(4-10)
Testing
Third-party HPLC, Mass Spec, Endotoxin
Storage
-20°C for up to 24 months
Solubility
Water-soluble
COA
Included with every order
Appearance
White to off-white powder
FAQ
Common questions about Semax
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide derived from the first four amino acids of adrenocorticotropic hormone (ACTH 4-10). It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s and has been approved in Russia as a prescription nootropic since 2011.
Reported measures include BDNF levels up to 1.4-fold baseline, changes in serotonergic and dopaminergic systems, neuroprotective endpoints in ischemic stroke models, cognitive and memory measures in animal studies, and anti-inflammatory markers.
Semax is not approved by the FDA for any medical use in the United States. It is approved in Russia as a prescription medication for cognitive disorders and stroke recovery. In the US, it is available only as a research peptide for in vitro laboratory use.
N-Acetyl Semax (NASA) has an acetyl group added to the N-terminus, which raises stability and resistance to enzymatic degradation. Half-life is correspondingly longer than standard Semax.
Lyophilized Semax should be stored at -20°C for long-term stability (up to 24 months). Protect from heat and direct light.
Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
