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The Eon standard
High Purity Guarantee
Your results are only as good as your compound. Every lot of KPV is tested by an independent ISO/IEC 17025-accredited lab in the USA. 99%+ purity isn't a target here. It's the requirement. Don't take our word for it: test any vial at an accredited lab of your choice. If HPLC purity comes back under 99%, we refund your order and pay for the test.
Size
10mg
Purity
99%+ by HPLC · guaranteed
Identity
Confirmed by mass spec
Lab
Freedom Diagnostics · ISO/IEC 17025
About this compound
KPV is a three amino acid peptide: lysine, proline, and valine. It is the tail end of a larger hormone called alpha-MSH. That tail carries the anti-inflammatory part of the sequence but not the part that affects skin color. Studies have measured its effect on NF-kB, a signaling pathway involved in inflammation. Its small size lets it enter cells through routes that larger peptides cannot use.
The numbers that define KPV and how it is being studied. For laboratory research use only.
3
Amino Acids
Lys-Pro-Val (α-MSH 11-13)
NF-κB
Pathway Target
Master inflammatory regulator
PepT1
Uptake Transporter
Carried into cells by the PepT1 transporter
4
Research Areas
Intestinal Inflammation Models
α-MSH Signalling
Epithelial Wound Closure
How It Works
How KPV works
The pathways KPV acts on - and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
Inflammatory Pathway Suppression
NF-κB Inhibition
At nanomolar concentrations, lower NF-κB and MAP-kinase pathway activation is measured in vitro. NF-κB is a principal regulator of inflammatory gene expression, and reduced secretion of TNF-α, IL-6 and IL-1β is recorded alongside.
Inhibits NF-κB and MAP-kinase signaling at nanomolar levels
Lower TNF-α, IL-6, IL-1β and other pro-inflammatory cytokines measured
Acts on inflammatory output rather than on anti-inflammatory cytokines
Cellular Transport & Action
PepT1-Mediated Uptake
Research shows KPV is taken up by cells via the PepT1 di/tripeptide transporter, which is expressed on immune cells and intestinal epithelial cells. This transporter-mediated uptake allows KPV to act intracellularly on inflammatory signaling.
Enters cells through the PepT1 peptide transporter
PepT1 is expressed on immune and intestinal epithelial cells
Enables intracellular modulation of inflammatory pathways
Melanocortin Fragment
α-MSH-Derived Activity
KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH 11-13). Most of α-MSH's anti-inflammatory activity has been attributed to this fragment, which also shows antimicrobial activity in vitro.
C-terminal tripeptide of the melanocortin peptide α-MSH
Carries much of α-MSH's anti-inflammatory activity
Antimicrobial effects reported against S. aureus and C. albicans
Uses & Applications
What KPV is researched for
The main areas KPV is being studied for - and the study-reported figures behind them.
GASTROENTEROLOGY
Intestinal Inflammation Models
PepT1-mediated uptake of KPV was followed by lower intestinal inflammation scores in DSS- and TNBS-induced colitis models.
IMMUNOLOGY
α-MSH Anti-Inflammatory Signaling
KPV is studied as the C-terminal tripeptide that carries much of α-MSH's anti-inflammatory and immunomodulating activity.
DERMATOLOGY
Epithelial Wound Closure
In a rabbit corneal model, topical KPV produced complete re-epithelialization by 60 hours, with a mechanism that may involve nitric-oxide signaling.
MICROBIOLOGY
Antimicrobial Activity
KPV shows antimicrobial effects against Staphylococcus aureus and Candida albicans across a broad concentration range in published research.
Study-reported magnitudes
Representative figures from published research. Bars fill as you scroll.
NF-κB ActivationInhibited
Pro-inflammatory Cytokines (TNF-α, IL-6)Measured
Colitis Severity (DSS / TNBS models)Scored
Corneal Re-epithelialization (rabbit study, 60 h)100% vs. 0% placebo
Figures are representative of published research findings and shown for reference.
Molecular Structure
The KPV molecule
An interactive 3D model rendered from the compound record - rotate and explore its structure.
C16H31N5O4
Molecular formula
C16H31N5O4
Molecular weight
342.43 g/mol
Sequence length
3 residues
Physical form
Lyophilized powder
Documented purity
≥99% by HPLC
Compound Information
Full specification
Chemical Name
KPV (Lys-Pro-Val)
Sequence
L-Lysyl-L-Prolyl-L-Valine (α-MSH 11-13)
Molecular Weight
342.43 g/mol
Molecular Formula
C₁₆H₃₁N₅O₄
Content
10 mg per vial
Form
Lyophilized powder
Purity
≥99% (HPLC verified)
Testing
Third-party HPLC, Mass Spec, Endotoxin
Storage
-20°C for long-term stability
Solubility
Water-soluble
COA
Included with every order
FAQ
Common questions about KPV
KPV is a tripeptide composed of lysine, proline and valine. It is the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH 11-13), and much of α-MSH's anti-inflammatory and immunomodulating activity has been attributed to this fragment.
At nanomolar concentrations, KPV inhibits the NF-κB and MAP-kinase inflammatory signaling pathways. NF-κB is a master regulator of inflammatory gene expression, so suppressing it lowers production of pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β in research models.
PepT1 is a di/tripeptide transporter expressed on immune cells and intestinal epithelial cells. Research shows KPV enters cells through PepT1, which allows it to act intracellularly on inflammatory signaling - a mechanism considered central to its effects in intestinal-inflammation models.
In DSS- and TNBS-induced mouse colitis models, PepT1-mediated uptake of KPV was followed by lower intestinal inflammation scores and reduced expression of pro-inflammatory cytokines including IL-1β, IL-6, IL-12, TNF-α and IFN-γ.
No. Despite roughly two decades of preclinical research across multiple organ systems, KPV has not completed human clinical trials. Research-grade KPV sold here is intended strictly for in vitro laboratory research and is not for human or veterinary use.
Lyophilized KPV should be stored at -20°C, protected from light and moisture, to preserve peptide integrity.
Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
