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The Eon standard
High Purity Guarantee
Your results are only as good as your compound. Every lot of GLP-1 S is tested by an independent ISO/IEC 17025-accredited lab in the USA. 99%+ purity isn't a target here. It's the requirement. Don't take our word for it: test any vial at an accredited lab of your choice. If HPLC purity comes back under 99%, we refund your order and pay for the test.
GLP-1 S is a selective GLP-1 receptor agonist peptide. Its sequence is about 94 percent identical to the endogenous GLP-1 hormone, with one change that resists enzymatic cleavage. Research has measured insulin release, appetite signalling and gastric emptying. A fatty acid chain lets it bind albumin, which extends its half-life.
The numbers that define GLP-1 S and how it is being studied. For laboratory research use only.
94%
Sequence Identity to GLP-1
Two substitutions vs native human GLP-1
0.38 nM
GLP-1R Binding Affinity
Measured affinity at the GLP-1 receptor
165h
Plasma Half-Life
Extended plasma half-life
4
Research Areas
Incretin Receptor Signaling
Glycemic Pathways
Cardiometabolic Research
How It Works
How GLP-1 S works
The pathways GLP-1 S acts on - and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
GLP-1 Receptor Agonism
GLP-1R
Selectively binds GLP-1 receptors. Published characterisation describes glucose-dependent insulin secretion, glucagon suppression and delayed gastric emptying in study models. Insulin response scales with glucose, a property examined relative to non-incretin secretagogues.
Glucose-dependent insulin secretion
Glucagon suppression
Delayed gastric emptying
Central GLP-1R Signalling
CNS
Engages GLP-1 receptors in the hypothalamus and hindbrain, with hunger, satiety and energy intake as the measured endpoints.
Food intake measured
Satiety signalling measured
Lower caloric intake
Extended Half-Life Design
PK
A C18 fatty-diacid chain confers reversible albumin binding and resistance to DPP-4 degradation, extending the plasma half-life to roughly 7 days in research models.
~165-hour half-life
Albumin-binding modification
DPP-4 resistant
Uses & Applications
What GLP-1 S is researched for
The main areas GLP-1 S is being studied for - and the study-reported figures behind them.
Metabolic
Metabolic Receptor Research
GLP-1 receptor agonism is a principal focus of metabolic research, and GLP-1 S is a selective agonist used as a reference compound in that work.
Endocrine
Glycemic Pathway Research
GLP-1 S is studied for glucose-dependent insulin secretion and glycemic endpoints in metabolic research.
Cardiometabolic
Cardiovascular Outcomes
Cardiometabolic signalling is a further area of research interest for this receptor class, beyond glucose handling.
Neuroscience
Hypothalamic & Reward Circuitry
GLP-1 receptor signaling in the hypothalamus and hindbrain modulates satiety and food-reward pathways, a focus of ongoing neuroscience research.
Study-reported magnitudes
Representative figures from published research. Bars fill as you scroll.
HPLC Purity (lot COA)≥99%
Sterility & Endotoxin ScreenPASSED
Net Content & IdentityPASSED
Figures are representative of published research findings and shown for reference.
Molecular Structure
The GLP-1 S molecule
An interactive 3D model rendered from the compound record - rotate and explore its structure.
C187H291N45O59
Molecular formula
C187H291N45O59
Molecular weight
4113.58 g/mol
Sequence length
31 residues
CAS / ID
910463-68-2
Physical form
Lyophilized powder
Documented purity
≥99% by HPLC
How Long It Lasts
Duration & clearance
How GLP-1 S clears from circulation, modeled from its documented ~~165 hours (~7 days) half-life. The curve draws as you scroll.
GLP-1 S · ~~165 hours (~7 days)
Reference · rapid clearance
Compound Information
Full specification
Compound Class
GLP-1 receptor agonist (incretin mimetic)
Research Name
GLP-1 S
Target
GLP-1 receptor (GLP-1R)
Form
Lyophilized powder
Molecular Weight
4,113.58 g/mol
Purity
≥99% (HPLC verified)
Testing
Third-party HPLC, Mass Spec, Endotoxin
Half-Life
~165 hours (~7 days)
Storage
-20°C for long-term stability
Solubility
Water-soluble
COA
Included with every order
FAQ
Common questions about GLP-1 S
GLP-1 S is a long-acting and selective GLP-1 receptor agonist. It mimics the incretin hormone GLP-1; published characterisation describes glucose-dependent insulin secretion, glucagon suppression, delayed gastric emptying and central appetite-pathway signalling.
GLP-1 S is a single-receptor (GLP-1) agonist. GLP-2 TZ is a dual GLP-1/GIP agonist, and GLP-3 RT is a triple GLP-1/GIP/glucagon agonist. The distinction is receptor coverage.
GLP-1 S has a molecular weight of 4,113.58 g/mol. Every vial is supplied at ≥99% purity, verified by HPLC, with a Certificate of Analysis included.
Store lyophilized vials at -20°C for long-term stability, protected from light and moisture.
No. GLP-1 S is sold strictly as a research compound for laboratory and in-vitro use only. It is not intended for human or animal consumption, diagnosis, or treatment.
Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.
