Peptide · Research Monograph · Synthetic tetrapeptide (Ala-Glu-Asp-Gly)

Epithalon

Telomere Lengthening Studies

Also known as Epitalon · AEDG peptide

Epithalon is a peptide made of four amino acids. It comes from epithalamin, a pineal gland extract studied in the Soviet Union. Studies have measured telomerase activity and telomere length in cultured human cells. Sleep-wake timing has been examined in animal models. At four amino acids, it is one of the shortest active sequences in the research literature.

Formula
C14H22N4O9
Mol. weight
390.35 Da
Length
4 residues
CAS
307297-39-8
View product & pricing → Lot records & COAs

For laboratory research use only - not for human or animal use

Epithalon vial from the Eon Peptides research catalog
Epithalon · 50mg · catalog photograph
Available in the Eon catalog - Epithalon from $85.00 View certificate of analysisThird-party verified · PDF

The molecule, in three dimensions

C14H22N4O9390.35
Drag to turn
Residues · hover to locate4 residues
Heavy atoms
27
Bonds
26
Composition
C14 N4 O9
Rings
None
Metal centre
None
Chain length
4 residues

Every heavy atom is placed from the sequence with ideal bond lengths and angles, so the connectivity is exact. The pose is idealised, an extended chain, and is not a measured conformation. Identity for the lot in stock is confirmed by LC-MS on its certificate.

Structure viewer →

Molecular data

Molecular formulaC14H22N4O9
Molecular weight390.35 Da
SequenceAla-Glu-Asp-Gly
Sequence length4 residues
CAS / identifier307297-39-8
Physical formLyophilized Powder
Available sizes50mg

How it works

  1. Telomerase

    Telomerase Activation & Telomere Biology

    In cultured human somatic cells, Epithalon has been reported to induce expression of the telomerase catalytic subunit (hTERT) and elongate telomeres, extending the proliferative capacity of the cultures in preclinical models.

    • Induction of hTERT expression in vitro
    • Telomere elongation in cultured fibroblasts
    • Extended proliferative lifespan of cell cultures
  2. Pineal / Circadian

    Pineal Peptide Signaling

    Modeled on the pineal gland peptide epithalamin, Epithalon has been studied for its influence on melatonin secretion rhythm and circadian regulation in rodent models of aging.

    • Based on the natural pineal peptide epithalamin
    • Studied for melatonin secretion rhythm
    • Circadian regulation in animal models
  3. Gene Expression

    Chromatin & Antioxidant Regulation

    Preclinical work reports that Epithalon can interact with DNA and modulate expression of genes associated with cellular senescence and antioxidant activity in animal tissue.

    • Proposed peptide-DNA interaction
    • Modulation of senescence-associated genes
    • Antioxidant enzyme expression in vitro

What the research shows

  1. Senescence

    Cellular Senescence

    Studied in cell-culture and rodent models for markers of replicative senescence and cellular lifespan.

  2. Chronobiology

    Circadian & Pineal

    Investigated for effects on melatonin rhythm and age-related changes in pineal function in animal models.

  3. Oxidative Stress

    Antioxidant Enzyme Activity

    Preclinical reports of lower lipid peroxidation and changes in antioxidant enzyme activity in aged animal tissue.

  4. Gerontology

    Age-Model Research

    Used as a reference tetrapeptide in rodent studies of lifespan, tumour incidence, and physiological aging markers.

Specification

Strength50mg
molecular_formulaC14H22N4O9
Molecular Weight390.35 g/mol
Purity>99% (HPLC)
FormLyophilized Powder
AppearanceWhite to off-white powder
Molecular FormulaAvailable on request
Verified Purity>99%
Quantity5mg
Lot NumberAssigned on shipment

How it's tested

Every lot of Epithalon released to the catalog carries a third-party certificate of analysis. 2 documented lots are on file for this compound, with reported HPLC purity from 99.42% to 99.75% (mean 99.59%), issued by Freedom Diagnostics. 1 of 2 certificates record identity as confirmed.

Documented lots
2
Reported purity
99.42% to 99.75%
Mean purity
99.59%
Issuing labs
Freedom Diagnostics

All certificates in the COA library →

Frequently asked questions

What is Epithalon?

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on epithalamin, a peptide isolated from the pineal gland. It has been studied primarily in gerontology research for telomerase activation and pineal/circadian biology in cell-culture and animal models.

Is Epithalon FDA approved?

No. Epithalon is not approved by the FDA or any regulatory agency for human use, and it is not a drug, supplement, or therapeutic product. It is supplied strictly as a reference compound for in-vitro laboratory research.

How should Epithalon be stored?

Store the lyophilized powder at −20°C or colder, protected from light, through the period indicated on the Certificate of Analysis. This is storage guidance for the researcher, not a shipping requirement.

What purity is this Epithalon?

Each lot is ≥99% pure by HPLC with identity confirmed by mass spectrometry, and ships with a third-party Certificate of Analysis documenting purity, net peptide content, and endotoxin screening.

  • PinealonTripeptide studied in neuronal oxidative-stress models
  • NAD+Cellular Energy Studies
  • SS-31Mitochondrial Function Studies
  • L-GlutathioneOxidative Stress Studies

For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.