EON RESEARCH LIBRARY // Article

Why disulfide connectivity needs explicit notation

Disulfide connectivity identifies which sulfur-containing groups are joined. Where several pairings are possible, the number of bonds alone does not fully describe the structure.

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Keep a source-provided connectivity map attached to the identity record. An intact mass observation and a detailed connectivity assignment are not identical evidence. State which one is actually available.

Reading checklist

Identify connected positions
Keep the connectivity source
Separate mass evidence from linkage evidence

Reference: Disulfide bonds in peptide identity.

Sources and further reading

IUPAC: amino acid and peptide nomenclature

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