EON RESEARCH LIBRARY // Article

What changes in a record when a peptide is cyclic

A linear peptide record and a cyclic peptide record differ in connectivity. Listing the same residue symbols does not eliminate that distinction.

For research use only. Not for human or veterinary use.

When a ring closure is specified, preserve its location and chemical description alongside the sequence. If a source gives only a two-dimensional drawing, retain that source and avoid reconstructing undocumented details in a text field.

Reading checklist

Record the closure description
Preserve the source structure
Do not rely on residue count alone

Reference: Cyclic peptide structures.

Sources and further reading

IUPAC: amino acid and peptide nomenclature

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